Immunohistochemical study of P53 protein expression in different prostate cancer Gleason grading groups

Gleason grading of prostate cancer. Contemporary approach.

Interobserver variability in Gleason histological grading of prostate cancer.

OBJECTIVE The aims of this study were to evaluate the reproducibility of the Gleason grading system and to compare its interobserver variability with the novel Gleason grade grouping proposal using a large sample volume. MATERIALS AND METHODS In total, 407 pathology slides of prostate needle biopsies from 34 consecutive patients with prostate cancer were re-evaluated. The International Societ...

Automated Prostate Cancer Diagnosis and Gleason Grading of Tissue Microarrays

We present the results on the development of an automated system for prostate cancer diagnosis and Gleason grading. Images of representative areas of the original Hematoxylin-and-Eosin (H&E)-stained tissue retrieved from each patient, either from a tissue microarray (TMA) core or whole section, were captured and analyzed. The image sets consisted of 367 and 268 color images for the diagnosis an...

An Immunohistochemical Study Of P63 Protein Expression In Meningioma

  Background and Objective: Histological grading has prognostic and therapeutic implications in meningioma. However, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. P63 gene is a novel P53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. In this stu...

Immunohistochemical Comparison of p53 Expression, Intensity and Distribution in Different Papillary Urothelial Cancers

Background: Given the importance of differential diagnosis of different papillary urothelial cancers, expression, intensity and distribution of p53 were evaluated in different bladder cancers using immunohistochemistry. Materials and Methods: In a retrospective study, archived samples of patients with different papillary urothelial cancers in Shohaday-e-Khalij Fars Hospital were selected. The s...